FATE-MAPPING AND FUNCTIONAL DISSECTION REVEAL PERILOUS INFLUENCE OF TYPE I INTERFERON SIGNALING IN MOUSE BRAIN AGING

Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging

Abstract Background Aging significantly elevates the risk of developing neurodegenerative diseases.Neuroinflammation is a universal hallmark of neurodegeneration as well as normal brain aging.Which branches of age-related neuroinflammation, and how they precondition the brain toward pathological progression, remain ill-understood.The presence of el

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Taxonomic difference in marine bloom-forming phytoplanktonic species affects the dynamics of both bloom-responding prokaryotes and prokaryotic viruses

ABSTRACTThe production of dissolved organic matter during phytoplankton blooms and consumption by heterotrophic prokaryotes promote marine carbon biogeochemical cycling.Although prokaryotic viruses presumably affect this process, their dynamics during blooms are not fully understood.Here, we investigated the effects of taxonomic difference in bloom

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Organization of medical caremajor sporting events

Organization of medical support for major international events is one of the major challenges for organizers.There is no single supranational detailed normative act yet.Objective: to analyze the existing national and international regulatory framework for the regulation of medical support for competitions with the subsequent formation of a general

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